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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
219

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Related Experiment Video

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Acoustic deep brain modulation: Enhancing neuronal activation and neurogenesis.

Hwichan Ham1, Kyu Sik Kim2, Jee-Hwan Lee3

  • 1Department of Aerospace Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.

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|September 1, 2024
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Summary

This study optimized shock wave deep brain modulation (DBM) for treating brain diseases. The new protocol enhances neural activity and neurogenesis without damage, offering a promising non-invasive therapeutic approach.

Keywords:
Brain stimulationElectroceuticalsFocused shockwaveNeurogenesisNeuromodulationNon-invasive

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Area of Science:

  • Neuroscience
  • Biomedical Engineering

Background:

  • Non-invasive deep brain modulation (DBM) is a promising therapy for brain diseases.
  • Acoustic DBM, using focused ultrasound or shock waves, offers targeted modulation but requires optimized parameters.
  • Current understanding of acoustic DBM's mechanistic effects and outcomes is limited.

Purpose of the Study:

  • To develop a robust shock wave DBM protocol by optimizing stimulation parameters.
  • To evaluate the efficacy of this optimized protocol in preclinical models.
  • To investigate the underlying neural and mechanical mechanisms.

Main Methods:

  • Utilized shock waves with a broad peak intensity spectrum (10-127 W/mm²) for extensive neuromodulation.
  • Compared various shock wave pressure profiles for DBM, assessing neural and behavioral responses.
  • Employed numerical analysis to understand the mechanical dynamics within the brain.

Main Results:

  • An optimized shock wave profile enhanced neuronal activity in the mouse hypothalamus.
  • The optimized protocol increased hippocampal neurogenesis without causing neuronal damage.
  • Observed reduced locomotion in behavioral tests, with no significant impact on spatial memory.

Conclusions:

  • An optimized shock wave stimulation protocol for non-invasive DBM was established.
  • The protocol selectively modulates deep brain neural functions.
  • This optimized DBM protocol offers potential for novel non-invasive therapeutic devices for brain diseases.