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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

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Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
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Perspective: Key Considerations When Developing and Publishing Dietary Interventions for Human Clinical Trials.

Heather J Leidy1, Rachel Gooding2, Kristen Hicks-Roof3

  • 1Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, United States; Department of Pediatrics, Dell Medical School, Austin, TX, United States.

The Journal of Nutrition
|September 1, 2024
PubMed
Summary

Incorporating herbs and spices can enhance the palatability of healthier foods, improving adherence to dietary guidelines and nutrition interventions. Detailed recipes, including these flavor enhancers, are crucial for research reproducibility and clinical practice.

Keywords:
clinical nutrition researchclinical recipesdietary interventionsherbs and spicesnutrition intervention guidance

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Area of Science:

  • Nutrition Science
  • Dietary Interventions
  • Public Health

Background:

  • Dietary Guidelines for Americans (2020-2025) promote personalized, culturally sensitive eating habits for a high-quality diet.
  • Reducing intake of saturated fat, sodium, and added sugars is challenging due to the palatability of commonly consumed American foods.
  • Adherence to healthier dietary patterns in nutrition studies is often low, attributed to factors like reduced taste, flavor, and familiarity.

Purpose of the Study:

  • To explore best practices for developing culturally appropriate recipes in human clinical trials.
  • To enhance dietary adherence and acceptability within nutrition interventions.
  • To highlight the role of herbs and spices in making healthier food options more appealing.

Main Methods:

  • This perspective article was informed by a Satellite Session at Nutrition 2023, focusing on recipe development for clinical trials.
  • The session discussed proposed guidelines for creating culturally sensitive and palatable dietary interventions.
  • Emphasis was placed on the importance of detailed recipe information, including specific foods, preparation methods, and the use of herbs and spices.

Main Results:

  • Herbs and spices show promise in maintaining the acceptability of healthier food options.
  • Detailed inclusion of food types, amounts, preparation methods, and recipes is necessary for intervention reproducibility.
  • Culturally appropriate recipe development is key to improving dietary adherence in clinical trials.

Conclusions:

  • Integrating personal, cultural, and traditional preferences is vital for establishing high-quality diets.
  • Herbs and spices can significantly improve the palatability and acceptance of healthier foods in nutrition interventions.
  • Standardized and detailed recipe information, including herbs and spices, is essential for translatability in research, guidelines, and practice.