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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

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Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
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Basic Research on Candida Species.

Masahiro Abe1, Yuki Kinjo2,3, Takuro Koshikawa1,4

  • 1Department of Fungal Infection, National Institute of Infectious Diseases.

Medical Mycology Journal
|September 1, 2024
PubMed
Summary
This summary is machine-generated.

This review explores Candida species infections, detailing mechanisms of superficial and invasive candidiasis. Research highlights Candida albicans in ocular infections and Candida auris in gastrointestinal issues, suggesting new therapeutic targets.

Keywords:
Candida speciesbiofilmendogenous candidiasisocular candidiasisvulvovaginal candidiasis

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Candida species are significant human pathogens causing diverse infections.
  • Limited research exists on the underlying mechanisms of candidiasis.
  • This review consolidates previous research on Candida pathogenesis.

Purpose of the Study:

  • To review mechanisms of superficial and invasive candidiasis.
  • To investigate Candida species virulence and host fitness.
  • To identify potential therapeutic targets for candidiasis.

Main Methods:

  • Ocular candidiasis mouse model and epidemiological research.
  • In vitro studies on Candida auris colonization and dissemination.
  • Investigation of invariant natural killer T cell responses in vulvovaginal candidiasis.
  • Evaluation of Candida species biofilm formation under varying oxygen concentrations.

Main Results:

  • Candida albicans strongly associated with ocular candidiasis.
  • Invasive Candida auris strains exhibit enhanced gastrointestinal colonization and dissemination.
  • Invariant natural killer T cells show protective roles in vulvovaginal candidiasis.
  • Candida tropicalis demonstrates increased biofilm formation in hypoxic conditions.

Conclusions:

  • Understanding candidiasis mechanisms is crucial for infection control.
  • Specific Candida species exhibit distinct pathogenic strategies.
  • Invariant natural killer T cells and oxygen concentration are key factors in Candida infections.