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Impact of imaging-diagnosed sarcopenia on outcomes in patients with biliary tract cancer after surgical resection: a systematic review and meta-analysis

  • 0Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
World Journal of Surgical Oncology +

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September 1, 2024

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September 1, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Sarcopenia is linked to worse survival and higher complication rates in biliary tract cancer patients after surgery. This finding highlights sarcopenia as a potential prognostic indicator for surgical outcomes in these patients.

Area Of Science

  • Oncology
  • Surgical Outcomes
  • Geriatrics

Background

  • Sarcopenia is associated with poor prognosis in cancer patients.
  • The impact of sarcopenia on biliary tract cancer (BTC) surgical outcomes is not well-defined.

Purpose Of The Study

  • To systematically review and summarize the evidence on sarcopenia's association with outcomes in patients with biliary tract cancer (BTC) undergoing surgical resection.

Main Methods

  • A systematic literature search was performed across major databases (PubMed, Embase, Web of Science, Cochrane Library) up to March 2024.
  • Data on overall survival (OS), recurrence-free survival (RFS), and postoperative complications were extracted from 26 studies involving 4292 patients.
  • Statistical analysis included meta-analysis, heterogeneity assessment, subgroup analyses, and publication bias evaluation.

Main Results

  • Sarcopenia was significantly associated with reduced OS (adjusted HR: 2.03) and poorer RFS (adjusted HR: 2.15) in BTC patients post-surgery.
  • Sarcopenia may also increase the risk of major postoperative complications (OR: 1.22).
  • No significant publication bias was detected.

Conclusions

  • Sarcopenia is a significant predictor of poorer overall survival in patients with biliary tract cancer following surgical resection.
  • Sarcopenia may also indicate worse recurrence-free survival and a higher likelihood of postoperative complications.
  • Further research is needed to standardize sarcopenia definitions and validate these prognostic findings.

Keywords: