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T1 and T2 measurements across multiple 0.55T MRI systems using open-source vendor-neutral sequences
Kathryn E Keenan1, Bilal Tasdelen2, Ahsan Javed3
1National Institute of Standards and Technology, Boulder, Colorado, USA.
Magnetic Resonance in Medicine
|September 2, 2024
Summary
Quantitative T1 and T2 measurements at 0.55T MRI are consistent between prototype and commercial systems. This finding applies to both phantom and healthy participant data, ensuring reliable imaging across different hardware.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Biomedical Engineering
- Medical Physics
Background:
- Standardization of quantitative MRI measurements is crucial for reliable clinical applications.
- Assessing the comparability of prototype and commercial MRI systems ensures hardware interoperability and consistent diagnostic accuracy.
- 0.55T MRI systems offer a balance between cost and image quality, making them relevant for various clinical settings.
Purpose of the Study:
- To compare T1 and T2 relaxation time measurements between prototype and commercial 0.55T MRI systems.
- To evaluate the consistency of quantitative MRI metrics using vendor-neutral pulse sequences and analysis methods.
- To assess the performance of 0.55T MRI systems in both phantom and healthy participant studies.
Main Methods:
- Utilized standard spin echo and abbreviated protocols for T1, B1, and T2 measurements on four 0.55T MRI systems (two prototype, two commercial).
- Employed an ISMRM/NIST system phantom for phantom studies and imaged five healthy participants across all systems.
- Compared phantom measurements to NMR-based references for accuracy and assessed reproducibility and system differences using both phantom and in vivo data.
Main Results:
- Successfully implemented vendor-neutral pulse sequences and reconstruction methods, with code made freely available.
- Demonstrated no statistically significant differences in mean T1 and T2 relaxation times between prototype and commercial systems in healthy participants.
- Observed no significant differences in phantom T1 and T2 measurements between the prototype and commercial systems using the abbreviated protocol.
Conclusions:
- Quantitative T1 and T2 measurements at 0.55T are statistically comparable across prototype and commercial MRI systems.
- The findings support the interchangeability of prototype and commercial 0.55T MRI hardware for quantitative imaging.
- Vendor-neutral approaches ensure consistent quantitative MRI results regardless of system manufacturer.
