Related Experiment Video

Updated: Jun 14, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.3K

Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis

Li-Ming Guo1, Zhi-Hui Jiang2, Hong-Zhen Liu3,4

  • 1Department of General Surgery, Qingdao Women and Children's Hospital, Qingdao 266000, Shandong Province, China. guolimingqdfe@163.com.

World Journal of Gastrointestinal Surgery
|September 2, 2024
PubMed

Insights

The combined systemic immune-inflammation index (SII) and pediatric appendicitis score (PAS) effectively predict disease severity and surgical outcomes in children with appendicitis. This combined model aids in clinical decisions for pediatric appendicitis management.

Area of Science:

  • Pediatric Surgery
  • Inflammatory Markers
  • Diagnostic Accuracy

Background:

  • Pediatric appendicitis is a frequent cause of abdominal pain in children, posing a surgical emergency.
  • Timely diagnosis is crucial to avert complications like perforation and peritonitis.

Purpose of the Study:

  • To evaluate the predictive capability of the systemic immune-inflammation index (SII) alongside the pediatric appendicitis score (PAS) for assessing appendicitis severity and surgical outcomes.
  • To investigate the combined SII and PAS model's utility in children aged 5 years and older.

Main Methods:

  • Analysis of clinical data from 104 children diagnosed with acute appendicitis.
  • Categorization into acute vs. chronic appendicitis and good vs. poor prognosis groups.
  • Measurement of SII and PAS, followed by construction of a joint predictive model.

Main Results:

  • Significant differences in SII and PAS were noted between acute and chronic appendicitis groups.
  • The combined SII and PAS model showed strong predictive value for disease severity (AUC = 0.914) and surgical outcomes (AUC = 0.857).
  • Correlation confirmed associations between SII, PAS, and disease severity.

Conclusions:

  • Integrating SII with PAS shows promise for assessing severity and predicting outcomes in pediatric appendicitis.
  • The combined SII and PAS model offers clinical utility for decision-making and optimizing surgical strategies in pediatric appendicitis.
Abstract

Keywords:
Disease severityLogistic regressionPediatric appendicitis scoreReceiver operating characteristic analysisRisk factorSurgical outcomesSystemic immune-inflammation index

More Related Videos

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

31.7K
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch00:08

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

9.9K

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
99
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
72
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
328
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
159
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
205
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
111