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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Physiology of the Gastrointestinal System III: Elimination01:26

Physiology of the Gastrointestinal System III: Elimination

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The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
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Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Feces Formation and Defecation01:26

Feces Formation and Defecation

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After spending 3 to 10 hours in the large intestine, chyme loses a lot of water and becomes feces, the final product of digestion. Feces consist of undigested dietary fiber such as cellulose, mucus, sloughed-off epithelial cells, and microbes. The descending and sigmoid colon stores feces and uses haustral contractions to dry it out but retains enough water to give it a semi-solid texture.
The mass peristalsis then pushes the feces into the rectum, which stretches the rectal walls to activate...
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Digestive Functions of the Large Intestine01:20

Digestive Functions of the Large Intestine

380
The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
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Related Experiment Video

Updated: Jun 14, 2025

Robotic Myotomy and Partial Fundoplication for Achalasia
11:19

Robotic Myotomy and Partial Fundoplication for Achalasia

Published on: August 11, 2023

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Problems with repairing gut sphincters malfunctions.

Mauro Bortolotti1

  • 1Department of Internal Medicine and Gastroenterology, S Orsola-Malpighi Polyclinic, University of Bologna, Bologna 40138, Italy. bormau@tin.it.

World Journal of Gastrointestinal Surgery
|September 2, 2024
PubMed
Summary
This summary is machine-generated.

Sphincter malfunction correction is challenging due to dual functions. Bioengineering aims to create safer artificial sphincters (ASs) overcoming current device limitations and adverse events.

Keywords:
Anal sphincterArtificial sphincterFecal incontinenceGastroesophageal refluxGastroesophageal sphincterMagnetic sphincterSphincter

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Area of Science:

  • Gastroenterology and Bioengineering
  • Biomedical Device Development

Background:

  • Sphincter repair is complex, risking damage to opposing functions like closure and opening.
  • Existing treatments for lower esophageal sphincter (LES) and anal sphincter dysfunction have significant drawbacks.
  • Artificial sphincters (ASs) offer a mechanical solution but present risks like infection and tissue damage.

Discussion:

  • Current ASs utilize diverse mechanisms (hydraulic, magnetic, mechanical) with intricate components.
  • Complications include infections, fibrosis, device malfunction, ischemia, and tissue erosion.
  • Despite limitations, some ASs are in clinical use, while others remain experimental.

Key Insights:

  • Sphincter repair requires balancing opposing functional needs.
  • Artificial sphincters present a viable but imperfect alternative to surgical repair.
  • Device-related complications necessitate further innovation in AS design.

Outlook:

  • Bioengineering approaches are crucial for developing safer, more effective biomimetic ASs.
  • Addressing biomechanical and biological interactions is key to improving AS performance.
  • Future research focuses on minimizing adverse events and enhancing functional restoration.