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Altered brain activity associated with premature ejaculation improved by electroacupuncture in rats.

Ning Wu^1,2, Jian-Huai Chen³, Tong Wang¹

¹Department of Andrology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China.

Sexual Medicine

|September 2, 2024

Summary

Electroacupuncture (EA) treatment for premature ejaculation (PE) in rats reduced ejaculation frequency and extended latency by modulating brain activity. These findings offer insights into PE mechanisms and potential therapeutic strategies.

Keywords:

electroacupuncture fractional amplitude of low frequency fluctuation functional magnetic resonance imaging premature ejaculation regional homogeneity resting-state

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Published on: December 22, 2016

Area of Science:

Neuroscience
Integrative and Complementary Medicine
Urology

Background:

Premature ejaculation (PE) is associated with altered brain activity.
Electroacupuncture (EA) has shown potential in modifying this brain activity for PE treatment.

Purpose of the Study:

To investigate the central pathological mechanisms of EA in treating PE.
To explore how EA influences brain activity related to ejaculatory behavior.

Main Methods:

Male Sprague-Dawley rats were divided into PE and control groups.
EA was applied to the Zusanli acupoint (ST-36) for 4 weeks.
Magnetic resonance imaging (MRI), behavioral tests, and plasma norepinephrine levels were assessed.

Main Results:

EA treatment decreased ejaculation frequency and increased latency in PE rats.
Norepinephrine levels correlated with ejaculation parameters.
EA modulated fractional amplitude of low frequency fluctuation (fALFF) and regional homogeneity (ReHo) in specific brain regions.

Conclusions:

EA at ST-36 may reduce ejaculation frequency and extend latency in PE rats.
These effects are likely mediated by EA's influence on brain activity.
Findings may inform new targeted therapies for PE.