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Tyrosine kinases: multifaceted receptors at the intersection of several neurodegenerative disease-associated

Max Stevenson1, Norah K Algarzae2, Charbel Moussa1

  • 1The Laboratory for Dementia and Parkinsonism, Translational Neurotherapeutics Program, Department of Neurology, Georgetown University Medical Center, Washington, DC, United States.

Frontiers in Dementia
|September 2, 2024
PubMed

Insights

Tyrosine kinase inhibitors (TKIs) show promise for treating neurodegenerative diseases (NDDs) by targeting shared mechanisms with cancer, like inflammation and protein degradation. This review explores TKs as therapeutic targets for NDDs.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Pharmacology

Background:

  • Tyrosine kinases (TKs) are enzymes crucial for cellular signaling, often dysregulated in diseases.
  • Tyrosine kinase inhibitors (TKIs) are established cancer therapeutics targeting TK activity.
  • Convergent molecular mechanisms exist between cancer and neurodegenerative diseases (NDDs).

Purpose of the Study:

  • To review the role of specific TKs in neurodegenerative processes.
  • To explore the potential of TKIs as a therapeutic strategy for NDDs.
  • To identify TK targets and pharmacological agents for NDD treatment.

Main Methods:

  • Literature review of scientific articles on tyrosine kinases, inhibitors, cancer, and neurodegenerative diseases.
  • Analysis of overlapping pathological pathways between cancer and NDDs.
  • Identification of TKs implicated in neuroinflammation, protein aggregation, and vascular remodeling.

Main Results:

  • TKs play distinct roles in processes relevant to NDDs, including inflammation and protein clearance.
  • TKIs may offer a therapeutic approach by modulating these shared pathways.
  • Several TKs are being investigated as targets for NDD interventions.

Conclusions:

  • Tyrosine kinase inhibition presents a promising therapeutic avenue for neurodegenerative diseases.
  • Targeting TKs could address key pathological features of NDDs, such as neuroinflammation and protein misfolding.
  • Further research into TKIs for NDDs is warranted.
Keywords:
autophagyblood vesselsc-KITinflammationneurodegenerative diseasestyrosine kinase

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