Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Amrinone in acute and long-term therapy].

M Klepzig, E Kleinhans, U Büll

    Zeitschrift Fur Kardiologie
    |February 1, 1985
    PubMed
    Summary

    Amrinone effectively improves heart function in patients with heart failure, enhancing cardiac output and exercise tolerance. However, careful patient selection and monitoring are crucial due to potential side effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Determinants of long-term follow-up after stent implantation in acute myocardial infarction].

    Zeitschrift fur Kardiologie·2002
    Same author

    [Autonomic dysfunction in cardiopulmonary diseases].

    Der Internist·2002
    Same author

    [Autonomic dysfunction in heart diseases and diabetes mellitus. Monitoring and diagnosis].

    Der Internist·2002
    Same author

    Successful thrombolysis of st. Jude medical aortic prosthesis with tissue-type plasminogen activator in a pregnant woman: a case report.

    Cardiology in review·2002
    Same author

    Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy.

    Cardiology·2002
    Same author

    [Cardiological diagnosis in patients with obstructive sleep apnea].

    Deutsche medizinische Wochenschrift (1946)·2002

    Area of Science:

    • Cardiology
    • Pharmacology

    Context:

    • Patients with cardiomyopathy or coronary artery disease and left heart failure often experience impaired cardiac function.
    • Positive inotropic agents with vasodilating properties are investigated for therapeutic benefits.

    Purpose:

    • To evaluate the acute and chronic therapeutic effects of amrinone, a positive inotropic and vasodilating agent.
    • To assess amrinone's impact on hemodynamic parameters and exercise tolerance in patients with heart failure.

    Summary:

    • Intravenous amrinone (1.5 mg/kg) reduced pulmonary and wedge pressures by 26% and 27% respectively, while increasing cardiac index by 18% in 15 patients.
    • Oral amrinone (avg. 300 mg/day) improved exercise tolerance by 22% and 13% after 2 and 12 weeks, respectively, in 35 patients.
    • Cardiac output increased significantly with oral amrinone therapy during maximal workload.
    • Side effects including nausea, orthostasis, angina, and hepatotoxicity were observed in 23 of 35 patients.

    Impact:

    • Amrinone demonstrates hemodynamic effectiveness both intravenously and orally in heart failure patients.
    • The study highlights the need for careful patient selection and frequent monitoring due to observed adverse effects.
    • Amrinone offers a potential therapeutic option for managing left heart failure, balancing efficacy with safety considerations.

    Related Experiment Videos