Assessment of LINC-PINT genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study found that LINC-PINT gene polymorphisms are linked to esophageal squamous cell carcinoma (ESCC) risk. Specific single nucleotide polymorphisms (SNPs) like rs157916 and rs157928 showed a decreased risk in the Hainan Han population.
Area Of Science
- Genetics
- Oncology
- Molecular Biology
Background
- Esophageal squamous cell carcinoma (ESCC) presents significant global health challenges due to high incidence and mortality rates.
- Understanding the genetic factors influencing ESCC susceptibility is crucial for developing effective prevention and treatment strategies.
Purpose Of The Study
- To investigate the association between LINC-PINT gene polymorphisms and the risk of developing ESCC.
- To identify specific single nucleotide polymorphisms (SNPs) within LINC-PINT that correlate with ESCC susceptibility in the Hainan Han population.
Main Methods
- A case-control study involving 391 ESCC patients and 452 healthy controls from the Hainan Han population.
- Genotyping of LINC-PINT SNPs and statistical analysis using odds ratios (OR) and 95% confidence intervals (CIs).
- Multifactor dimensionality reduction (MDR) analysis was employed to assess SNP-SNP interactions and their combined effect on ESCC risk.
Main Results
- The study identified specific LINC-PINT SNPs (rs157916, rs157928, rs16873842, rs7801029, rs7781295) associated with a reduced risk of ESCC.
- Stratified analyses revealed that certain SNPs conferred protection in specific demographic groups, including males, females, older individuals (>64 years), non-drinkers, smokers, and drinkers.
- A combination of six SNPs (rs157916, rs16873842, rs7801029, rs7781295, rs28662387, and rs157928) emerged as the most effective predictive model for ESCC risk.
Conclusions
- LINC-PINT gene polymorphisms are significantly associated with the risk of esophageal squamous cell carcinoma.
- Certain LINC-PINT SNPs may act as protective factors against ESCC, with varying effects depending on individual characteristics and lifestyle factors.
- The identified SNP combination offers a potential tool for risk assessment and personalized prevention strategies for ESCC.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...