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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

824

Metabolic syndrome traits differentially and cumulatively influence micro- and macrovascular disease risk in patients

Alex E Henney1,2,3, David R Riley1,2, Theresa J Hydes1,2,3

  • 1Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.

Liver International : Official Journal of the International Association for the Study of the Liver
|September 2, 2024
PubMed
Abstract

Insights

Metabolic dysfunction-associated steatotic liver disease (MASLD) increases micro- and macrovascular disease risk, especially with more metabolic syndrome (MetS) components. This risk is highest in women, highlighting the need for aggressive management.

Area of Science:

  • Hepatology
  • Cardiology
  • Endocrinology

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent.
  • The combined effect of metabolic syndrome (MetS) components on vascular complications in MASLD patients remains unclear.
  • Understanding these risks is crucial for patient management and preventative strategies.

Purpose of the Study:

  • To investigate the association between the number of MetS components and the risk of micro- and macrovascular diseases in patients with MASLD.
  • To determine the differential impact of specific MetS components on vascular outcomes.
  • To explore the influence of sex on these associations.

Main Methods:

  • Retrospective cohort study using the TriNetX global federated database.
  • Patients with hepatic steatosis and at least one MetS component were compared to a control group without these conditions.
  • Propensity score matching and 5-year follow-up were employed to analyze microvascular and macrovascular outcomes.

Main Results:

  • MASLD with insulin resistance showed the highest risk for microvascular disease (HR 13.93).
  • MASLD with hypertension demonstrated the highest risk for macrovascular disease (HR 7.23).
  • MASLD with all MetS components presented the greatest risk for both microvascular (HR 31.20) and macrovascular (HR 8.04) diseases, with a pronounced effect in women.

Conclusions:

  • The number of MetS components significantly increases micro- and macrovascular disease risk in MASLD patients.
  • Specific MetS components have differential effects on micro- and macrovascular complications.
  • Aggressive management of metabolic risk factors is essential for preventing vascular complications in MASLD, particularly in women.
Keywords:
MASLDmacrovascular diseasemetabolic syndromemicrovascular diseasetype 2 diabetes

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