Related Experiment Video
Updated: Jun 14, 2025
08:01
A Web Tool for Generating High Quality Machine-readable Biological Pathways
Published on: February 8, 2017
17.6K
Enteropathway: the metabolic pathway database for the human gut microbiota
Hirotsugu Shiroma1, Youssef Darzi1,2, Etsuko Terajima1
1School of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 M6-3 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.
Briefings in Bioinformatics
|September 2, 2024
Summary
Enteropathway is a new database detailing human gut microbial metabolic pathways. It offers a comprehensive resource for researchers studying the gut microbiome and host metabolism.
Area of Science:
- Microbiology
- Metabolomics
- Bioinformatics
Background:
- The human gut microbiota produces numerous metabolites impacting host physiology.
- Existing metabolic pathway databases lack comprehensiveness for gut microbial metabolites.
Purpose of the Study:
- To present Enteropathway, a novel, comprehensive metabolic pathway database for the human gut microbiota.
- To provide a tool for visualizing and analyzing microbial metabolic pathways and their host interactions.
Main Methods:
- Integrated 3269 compounds, 3677 reactions, and 876 modules from 1012 curated scientific literature.
- Developed a web application for graphical visualization, customization, and enrichment analysis.
- Ensured novelty with 698 new modules not found in other databases.
Main Results:
- Enteropathway database established with extensive data on gut microbial metabolism.
- Web application provides interactive visualization and statistical analysis tools.
- Identified 698 novel metabolic modules.
Conclusions:
- Enteropathway serves as a valuable, comprehensive reference complementing existing databases.
- The tool facilitates deeper understanding of the gut microbiota-host metabolism interplay.
- Enables researchers to uncover new insights into microbial metabolite functions.
