Related Experiment Video
Updated: Jun 14, 2025
Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain
Published on: June 6, 2025
Long-Term Effects of Individualized Acupuncture for Chronic Neck Pain : A Randomized Controlled Trial
Ling Zhao1, Mingsheng Sun1, Zihan Yin1
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (L.Z., M.S., Z.Y., G.G., J.Chen, D.C., H.Z., F.L.).
Background:
Long-term effects of individualized acupuncture in persons with chronic neck pain (CNP) remain unknown.
Objective:
To evaluate the efficacy and safety of pressure pain, sensory-based individualized acupuncture for relieving CNP.
Design:
A 24-week multicenter randomized controlled clinical trial. (ChiCTR1800016371).
Setting:
Outpatient settings at 4 clinical centers in China from May 2018 to March 2020.
Participants:
716 participants with CNP.
Intervention:
Participants were randomly assigned to a waiting list (WL) group or to 1 of 3 interventions, which consisted of 10 sessions over 4 weeks: higher sensitive acupoints (HSA), lower sensitive acupoints (LSA), and sham acupoints (SA) acupuncture groups.
Measurements:
The primary outcome was the change in the visual analogue scale (VAS) score for neck pain (range, 0 to 100) from baseline to 4 weeks, with a difference of 10 points considered the minimum clinically important threshold. The VAS was also assessed every 4 weeks through 24 weeks.
Results:
The modified intention-to-treat population included 683 participants. The mean baseline VAS was 50.36, 50.10, 49.24, and 49.16 for HSA, LSA, SA, and WL, respectively. Compared with a mean baseline to week 4 change of -12.16 in the HSA group, the mean changes were -10.19 in the LSA group (net difference [ND], -1.97 [95% CI, -5.03 to 1.09]), -6.11 in the SA group (ND, -6.05 [CI, -9.10 to -3.00]), and -2.24 in the WL group (ND, -9.93 [CI, -12.95 to -6.90]). The intervention effects persisted at 24-week follow-up.
Limitation:
Lack of complete blinding and limited generalizability.
Conclusion:
Individualized acupuncture interventions using high- or low-sensitivity acupuncture points were more effective in reducing CNP than SA and WL control groups sustained through 24 weeks, but the magnitude of relative improvement did not reach a minimal clinically important difference.
Primary Funding Source:
National Natural Science Foundation of China.
