Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients

Area of Science:

• Hematology
• Clinical Pathology
• Infectious Disease Diagnostics

Background:

• Immature platelet fraction (IPF) is explored for bacteremia differentiation.
• Its prognostic value in bacteremia remains uncertain.
• This study investigates IPF's predictive and prognostic capabilities.

Purpose of the Study:

• To confirm the predictive capability of IPF for bacteremia.
• To investigate the association between IPF and prognosis in bacteremia patients.
• To evaluate delta IPF as an early prognostic marker.

Main Methods:

• Retrospective analysis of patients with complete blood count (CBC) on blood culture day (D1) and preceding day (D0).
• Calculation of delta IPF (absolute difference between D1 and D0).
• Analysis of bacteremia prediction and correlation with 30-day mortality.

Main Results:

• Delta IPF ≥3.4% showed 97.3% specificity for predicting bacteremia.
• Combined delta IPF and procalcitonin improved sensitivity to 90.5%.
• Delta IPF ≥1.5% was independently associated with increased 30-day mortality (aOR: 3.88, p=0.020) and showed significant survival differences (p<0.001).

Conclusions:

• Delta IPF is a significant predictor of mortality in bacteremia patients.
• IPF aids not only in bacteremia detection but also in early prognosis.
• The study highlights the prognostic utility of delta IPF in early-stage bacteremia.