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Updated: Jun 14, 2025
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
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cGAS/STING signalling pathway in senescence and oncogenesis
Le Yu1, Pengda Liu1
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Seminars in Cancer Biology
|September 2, 2024
Summary
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway is vital for innate immunity and influences cellular senescence and cancer. Understanding its mechanisms offers new therapeutic strategies for these conditions.
Area of Science:
- Immunology
- Cellular Biology
- Oncology
Background:
- The cGAS/STING signaling pathway is a key part of the innate immune system.
- It senses cytosolic DNA and is involved in cellular senescence and cancer.
- Recent research illuminates its molecular mechanisms in various diseases.
Purpose of the Study:
- To review the biology of the cGAS/STING pathway.
- To explore its roles in senescence and oncogenesis.
- To discuss clinical implications and therapeutic potential.
Main Methods:
- Literature review of current knowledge on cGAS/STING signaling.
- Analysis of its involvement in senescence and cancer.
- Exploration of therapeutic strategies and challenges.
Main Results:
- The cGAS/STING pathway has critical roles in sensing DNA, regulating senescence, and influencing cancer.
- Its function in cancer is context-dependent, acting in both development and suppression.
- Emerging research highlights specific molecular mechanisms and pharmacological targets.
Conclusions:
- Targeting the cGAS/STING pathway holds significant therapeutic promise for senescence-related disorders and cancer.
- Further research into regulatory mechanisms and modulators is crucial.
- Advanced understanding could lead to novel treatments for challenging diseases.
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