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Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Updated: Jun 20, 2026

A Mouse Model for Laser-induced Choroidal Neovascularization

A Mouse Model for Laser-induced Choroidal Neovascularization

Published on: December 27, 2015

Macular neovascularization.

Jay U Sheth¹, Michael W Stewart², Raja Narayanan³

¹Department of Vitreoretinal Services, Shantilal Shanghvi Eye Institute, Mumbai, India.

Survey of Ophthalmology

|September 2, 2024

Summary

Macular neovascularization (MNV) involves abnormal blood vessel growth in the macula, often caused by VEGF. Early diagnosis using multimodal imaging and timely anti-VEGF treatment are crucial for preserving vision.

Keywords:

Age-related macular degeneration Anti-vascular endothelial growth factor Choroidal neovascular membrane Macular neovascularization Optical coherence tomography Pathological myopia Polypoidal choroidal vasculopathy

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Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Area of Science:

Ophthalmology
Retinal Diseases
Neovascularization

Background:

Macular neovascularization (MNV) is a complication of chorioretinal diseases like AMD, driven by VEGF.
Localized ischemia and inflammation trigger increased VEGF synthesis in retinal cells.
The CONAN study proposed 'macular neovascularization' to encompass various intraretinal and subretinal vessel types.

Purpose of the Study:

To review the etiology and clinical presentation of MNV.
To highlight the role of multimodal imaging in diagnosing MNV.
To discuss current therapeutic strategies for MNV.

Main Methods:

Literature review of MNV etiology, clinical features, imaging, and treatments.
Analysis of diagnostic modalities including OCT, OCT angiography, and fundus autofluorescence.
Evaluation of therapeutic options such as anti-VEGF injections, laser photocoagulation, PDT, and surgery.

Main Results:

MNV presents as a grey-green macular lesion with visual disturbances.
Multimodal imaging is essential for accurate diagnosis and treatment planning.
Intravitreal anti-VEGF injections are the primary treatment, with other modalities used adjunctively.

Conclusions:

Understanding MNV's origins and presentation is key.
Advanced imaging techniques improve diagnostic accuracy.
A range of treatments are available, with anti-VEGF therapy being the mainstay.