Natural resorcylic lactones derived from alternariol.
1Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Kaiserstraße 12, 76131 Karlsruhe, Germany.
Beilstein Journal of Organic Chemistry
|September 3, 2024
Summary
This review covers resorcylic lactones, fungal metabolites with diverse structures and biological activities. Research focuses on their isolation, synthesis, and potential applications, highlighting 127 known compounds.
Area of Science:
- Mycology
- Natural Product Chemistry
- Organic Chemistry
Background:
- Resorcylic lactones are secondary metabolites exclusively produced by fungi.
- These compounds are biosynthetically derived from alternariol.
- A diverse range of structural motifs are observed within this class of 127 known compounds.
Purpose of the Study:
- To provide a comprehensive overview of naturally occurring resorcylic lactones.
- To discuss their isolation, structure elucidation, biological activities, biosynthesis, and total synthesis.
- To highlight the significance of both frequently found and rarely isolated fungal metabolites.
Main Methods:
- Literature review and synthesis of existing research on resorcylic lactones.
- Analysis of structural diversity and biosynthetic pathways.
- Compilation of data on biological activities and synthetic approaches.
Main Results:
- Identification and characterization of 127 naturally occurring resorcylic lactones with varied structures.
- Detailed investigation of frequently isolated toxins like alternariol and its derivatives.
- Recognition of interesting biological activities in rarely found natural products.
Conclusions:
- Resorcylic lactones represent a significant class of fungal metabolites with broad structural diversity.
- Both common and rare resorcylic lactones exhibit notable biological activities, warranting further research.
- This overview consolidates current knowledge, guiding future investigations into these compounds.
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