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Pan-cancer analysis of the role of MPP7 in human tumors
Xiaotong Xu1, Weyland Cheng1, Shuai Zhao1
1Children's Hospital Affiliated to Zhengzhou University, 33 Longhu Waihuan East Road, Zhengzhou, Henan, 450018, PR China.
Abstract:
MAGUK p55 subfamily member 7, a part of the membrane palmitoylated protein subfamily, is an essential adapter that promotes epithelial cell polarity and has increasing significance in multiple cancers, including esophageal cancer, clear cell renal cell carcinoma, breast cancer, and pancreatic ductal adenocarcinoma. This paper aims to determine the effect of the MAGUK p55 subfamily member 7 in various tumor types using The Cancer Genome Atlas and Genotype-Tissue Expression database. A variety of software and web platforms, such as cBioPortal, GEPIA2, TIMER2, UALCAN, R, STRING, and DAVID, were used to obtain and analyze data. Notably, low expression of MAGUK p55 subfamily member 7 was observed in most cancers. In addition, low expression of MAGUK p55 subfamily member 7 predicted poor prognoses in cancer patients. Mutation was the most frequent genetic alteration type in MAGUK p55 subfamily member 7, with the phosphorylation sites identified as S412 and S490 in various cancers. Furthermore, expression of MAGUK p55 subfamily member 7 was associated with cancer-related fibroblasts and CD8+ T cells. Gene enrichment analysis indicated that MAGUK p55 subfamily member 7 influences cancer through the Rap1 signaling pathway. This paper elucidates the biological significance of MAGUK p55 subfamily member 7 in human pan-cancer prognosis and immune response.
Insights
MAGUK p55 subfamily member 7 (MPP7) is crucial for cell polarity and its low expression predicts poor cancer prognosis. This study reveals MPP7
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- MAGUK p55 subfamily member 7 (MPP7) is an adapter protein involved in epithelial cell polarity.
- MPP7 has emerging significance in various cancers, including esophageal, renal, breast, and pancreatic ductal adenocarcinoma.
Purpose of the Study:
- To investigate the role and prognostic value of MPP7 across diverse cancer types.
- To analyze genetic alterations, expression patterns, and immune cell associations of MPP7 in human cancers.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases.
- Employed bioinformatics tools: cBioPortal, GEPIA2, TIMER2, UALCAN, R, STRING, and DAVID for data analysis.
- Performed gene enrichment analysis to identify associated signaling pathways.
Main Results:
- Low MPP7 expression was observed in most analyzed cancers and correlated with poor patient prognosis.
- Mutations were the most common genetic alteration in MPP7, with S412 and S490 identified as key phosphorylation sites.
- MPP7 expression was linked to cancer-associated fibroblasts and CD8+ T cells, suggesting immune modulation.
Conclusions:
- MPP7 plays a significant role in human pan-cancer prognosis and immune response.
- The Rap1 signaling pathway is implicated in MPP7's influence on cancer development.
- MPP7 serves as a potential prognostic biomarker and therapeutic target in oncology.
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