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Ferritin light chain as a potential biomarker for the prognosis of liver hepatocellular carcinoma

  • 0Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, 133000, China.
Heliyon +

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September 3, 2024

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September 3, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High ferritin light chain (FTL) expression is linked to liver cancer progression and poor outcomes. This study highlights FTL as a potential diagnostic and prognostic marker for liver hepatocellular carcinoma (LIHC).

Area Of Science

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background

  • High expression of ferritin light chain (FTL) is implicated in cancer development and progression.
  • The role of FTL in pan-cancer progression and prognosis requires further investigation.

Purpose Of The Study

  • To conduct a pan-cancer analysis of FTL expression using public datasets.
  • To investigate the association of FTL with clinicopathological characteristics, DNA cycles, and immune infiltration in liver hepatocellular carcinoma (LIHC).
  • To evaluate the clinical diagnostic and prognostic value of FTL in LIHC.

Main Methods

  • Utilized various bioinformatics databases for pan-cancer analysis.
  • Performed differential expression analysis of FTL in cancer versus normal tissues.
  • Correlated FTL expression with clinicopathological features, DNA replication, and immune cell infiltration in LIHC.
  • Conducted validation experiments.

Main Results

  • FTL was found to be differentially expressed in pan-cancer tissues compared to normal tissues.
  • High FTL expression significantly correlated with clinicopathological characteristics in LIHC patients.
  • FTL expression was associated with altered DNA cycles and immune infiltration in LIHC.
  • FTL was identified as a potential diagnostic and prognostic marker for LIHC.

Conclusions

  • High FTL expression is associated with poor prognosis in LIHC patients.
  • FTL serves as a potential prognostic and immune marker for LIHC.
  • This study establishes a novel association between FTL and LIHC progression and outcome.

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