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Neurocardiac Axis Physiology and Clinical Applications
Caroline Plott1, Tarek Harb2, Marios Arvanitis2
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
International Journal of Cardiology. Heart & Vasculature
|September 3, 2024
Summary
The neurocardiac axis, linking the brain, heart, and immune system, is vital for homeostasis. Its dysfunction contributes to cardiovascular diseases like atherosclerosis and heart failure.
Area of Science:
- Cardiovascular Science
- Neuroimmunology
- Physiology
Background:
- The neurocardiac axis integrates cardiovascular, neural, and immune systems for maintaining homeostasis.
- Dysregulation, particularly from chronic stress and sympathetic activation, links this axis to cardiovascular pathologies.
Purpose of the Study:
- To review the normal function and pathophysiology of the neurocardiac axis.
- To explore its clinical implications in hypertension, atherosclerosis, and heart failure.
- To discuss quantification methods and future research directions.
Main Methods:
- Literature review of neurocardiac axis research.
- Analysis of its role in cardiovascular disease pathogenesis.
- Examination of current and emerging therapeutic strategies.
Main Results:
- The neurocardiac axis is crucial for physiological adaptation but implicated in disease development.
- Chronic stress and sympathetic overactivity are key contributors to its pathological states.
- Clinical implications span hypertension, atherosclerosis, and heart failure, with novel treatments emerging.
Conclusions:
- Understanding the neurocardiac axis is essential for comprehending and treating cardiovascular diseases.
- Targeting this axis offers potential therapeutic avenues for conditions like hypertension and heart failure.
- Further research and refined quantification methods are needed to fully elucidate its role.
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