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Updated: Jun 14, 2025
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Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity
Published on: March 7, 2019
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Physical activity, sedentary behavior, and risk of sepsis: a two-sample mendelian randomization study
Yang Zhang1,2, Yu Rong1,3, Jun Mao1,3
1The Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Frontiers in Medicine
|September 3, 2024
Summary
Engaging in moderate to vigorous physical activity (MVPA) and vigorous physical activity (VPA) may reduce sepsis risk. Conversely, prolonged sedentary behaviors like driving are linked to a higher risk of sepsis.
Area of Science:
- Genetics
- Epidemiology
- Public Health
Background:
- Sepsis is a life-threatening condition with significant public health implications.
- The role of physical activity and sedentary behavior in sepsis risk requires further elucidation.
- Understanding modifiable risk factors is crucial for developing effective prevention strategies.
Purpose of the Study:
- To investigate the potential causal relationship between physical activity, sedentary behavior, and sepsis risk.
- To evaluate the association of different physical activity intensities and sedentary behaviors with sepsis incidence.
- To provide evidence for lifestyle-based sepsis prevention.
Main Methods:
- Employed a two-sample Mendelian randomization approach using large-scale genome-wide association study data from UK Biobank and FinnGen.
- Assessed associations between genetically predicted physical activity (MVPA, VPA) and sedentary behaviors (driving, computer use, TV watching) with sepsis risk.
- Utilized inverse variance-weighted, weighted median, and MR-Egger methods for causal inference, with comprehensive sensitivity analyses.
Main Results:
- Moderate to vigorous physical activity (MVPA) showed a significant inverse association with sepsis risk (OR 0.47, P=0.0296).
- Vigorous physical activity (VPA) was also significantly inversely associated with sepsis risk (OR 0.19, P=0.0324).
- Prolonged driving time exhibited a significant positive association with increased sepsis risk (OR 3.99, P=0.0097).
Conclusions:
- This study suggests a causal protective effect of MVPA and VPA against sepsis.
- Prolonged sedentary behavior, specifically driving, may causally increase sepsis risk.
- Findings support the development of physical activity interventions for sepsis prevention.
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