Editorial: Endothelial activation and microcirculatory disorders in sepsis and critical illness, volume II
W Conrad Liles1,2,3,4, Jeremie Joffre5,6
1Department of Medicine (Primary), University of Washington, Seattle, WA, United States.
Frontiers in Medicine
|September 3, 2024
Abstract
No abstract available in PubMed .
Related Concept Videos
Inflammation
53.2K
Overview
53.2K
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K


