Comparative Study Analysis of Epstein-Barr Virus Infection: Tissue Versus Blood Samples in Patients With Prostatic Adenocarcinoma and Its Correlation With Clinicopathological Parameters

Imane Mharrach ¹, Kaoutar Anouar Tadlaoui ², Abdelilah Laraqui ^3,4,5

⁰Oncology, Faculty of Sciences and Techniques- Mohammedia, University Hassan II of Casablanca, Mohammedia, MAR.

Cureus +

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September 3, 2024

View abstract on PubMed

Summary

Epstein-Barr virus (EBV) is more prevalent in prostate cancer (PCa) tissues than blood. This oncogenic virus shows a correlation with PCa

Area Of Science

Oncology
Virology
Cancer Research

Background

Prostate cancer (PCa) is a leading cause of cancer mortality in men.
Epstein-Barr virus (EBV) is an oncogenic virus linked to various cancers, but its role in PCa is unclear.

Purpose Of The Study

To determine the prevalence of EBV in PCa patient blood and tissue samples.
To assess the correlation between EBV presence and PCa clinicopathological characteristics.

Main Methods

Prospective collection of 50 PCa blood and 50 tissue samples.
Detection of EBV DNA using polymerase chain reaction (PCR).
Statistical analysis of EBV prevalence against clinicopathological data.

Main Results

EBV DNA detected in 38% of blood and 64% of tissue samples (p=0.009).
Significant correlation found between EBV and Gleason score in tissue (p=0.041).
Significant correlation found between EBV and T-stage in blood (p=0.02).

Conclusions

Higher EBV prevalence in PCa tissues suggests a potential role in prostate cancer etiology.
EBV may serve as a biomarker for prostate cancer development and progression.
Further research is warranted to understand EBV's function in prostate carcinoma.

Keywords:

biomarker blood epstein-barr virus pcr prostate cancer tissue