Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

549
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
549
Pedigree Analysis01:35

Pedigree Analysis

84.1K
Overview
84.1K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.2K
Dementia01:30

Dementia

107
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
107

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advanced metal-phenolic networks for tissue regeneration: opportunities and challenges.

Journal of nanobiotechnology·2026
Same author

Hyperthyroidism Is Genetically Associated With Reduced Risk of Parkinson's Disease: A Mendelian Randomization Analysis.

The European journal of neuroscience·2026
Same author

How stratospheric intrusion modulates the optimal mitigation pathway for ozone under sharp emission reductions.

Ecotoxicology and environmental safety·2026
Same author

Sanguinarine as a multi-target therapeutic candidate for laryngeal cancer: insights from network pharmacology, molecular dynamics and in vitro validation.

BMC cancer·2026
Same author

Spatial distribution of the proteome in the human body and in cancers.

Nature·2026
Same author

Exploring the material basis and potential mechanism of spleen-strengthening and damp-resolving prescriptions in the treatment of diabetes mellitus complicated with obesity based on data mining, UPLC-Q-TOF-MS/MS and network pharmacology.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Related Experiment Video

Updated: Jun 14, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.6K

Related Factors with Vascular Dementia: A Two-Sample Mendelian Randomization Study.

Shang-Mei Cao1, Meng Luo2, Bo-Lin Chen1

  • 1Department of Science and Technology Innovation Center, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe, China.

Rejuvenation Research
|September 3, 2024
PubMed
Summary

Vascular dementia (VD) lacks effective treatments. Mendelian randomization identified N6-threonylcarbamoyladenosine (t⁶A) as a metabolite potentially influencing VD risk, offering new research avenues.

Keywords:
Mendelian randomizationmetabolitest6Avascular dementia

More Related Videos

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:19

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

412
Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
04:29

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Published on: May 17, 2024

573

Related Experiment Videos

Last Updated: Jun 14, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.6K
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:19

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

412
Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
04:29

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Published on: May 17, 2024

573

Area of Science:

  • Metabolomics
  • Neuroscience
  • Genetics

Background:

  • The pathogenesis of vascular dementia (VD) remains poorly understood, with no current effective prevention or treatment strategies.
  • Identifying causal factors is crucial for developing targeted interventions for VD.

Purpose of the Study:

  • To investigate the potential causal effect of metabolites on vascular dementia (VD) using Mendelian randomization (MR).
  • To explore the role of specific metabolites, such as N6-threonylcarbamoyladenosine (t⁶A), in VD development.

Main Methods:

  • Utilized summary statistics from large-scale Genome-Wide Association Studies (GWAS) for metabolites and VD.
  • Employed Mendelian randomization (MR) with genetic instruments derived from 32 single-nucleotide polymorphisms associated with metabolites.
  • Applied inverse-variance weighted, weighted median, MR-Egger regression, and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) tests for robust analysis.

Main Results:

  • Found strong evidence suggesting a positive causal effect of the metabolite N6-threonylcarbamoyladenosine (t⁶A) on vascular dementia (VD).
  • Inverse-variance weighted analysis showed an odds ratio (OR) of 0.667 (95% CI: 0.548-0.812, p < 0.001).
  • MR-Egger and weighted median methods corroborated these findings, indicating a significant association (p < 0.019 and p = 0.012, respectively).

Conclusions:

  • The metabolite N6-threonylcarbamoyladenosine (t⁶A) may be causally associated with vascular dementia (VD).
  • These findings highlight t⁶A as a potential therapeutic target or biomarker for VD.
  • Further research is warranted to elucidate the precise mechanisms underlying this association.