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cRGD-platelet@MnO/MSN@PPARα/LXRα Nanoparticles Improve Atherosclerosis in Rats by Inhibiting Inflammation and Reducing Blood Lipid

  • 0Department of Radiology, Liuzhou People's Hospital, Liuzhou, 545006, Guangxi, China.
Current Pharmaceutical Biotechnology +

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September 3, 2024

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September 3, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Novel nanoparticles effectively treat atherosclerosis by reducing inflammation and lowering harmful lipids. These cRGD-platelet-NPs show high safety and promote cholesterol efflux, offering a promising therapeutic strategy.

Area Of Science

  • Biomedical Engineering
  • Cardiovascular Research
  • Nanomedicine

Background

  • Atherosclerosis (AS) is a lipid-driven inflammatory arterial disease.
  • Existing treatments (LXRα and PPARα agonists) have limitations due to side effects.

Purpose Of The Study

  • To develop and evaluate a novel nanoparticle (NP) for AS treatment.
  • To investigate the NP's mechanism for inhibiting inflammation and reducing lipids in AS.

Main Methods

  • Synthesis of cRGD-platelet@MnO/MSN@PPARα/LXRα NPs (cRGD-platelet-NPs).
  • Assessment of NP size, safety, and targeting via DLS and immunofluorescence.
  • In vitro and in vivo evaluation of cell proliferation, apoptosis, inflammation, and plaque formation.
  • Western blot analysis of the NF-κB signaling pathway in rat aorta.

Main Results

  • Successful synthesis of cRGD-platelet-NPs (approx. 150 nm, PDI < 0.3) with high in vitro/in vivo safety.
  • Significant reduction in AS plaque formation and improved lipid profiles (lower LDL-C, TC, TG; higher HDL-C).
  • Decreased inflammatory markers and suppression of the NF-κB signaling pathway, promoting M2 macrophage polarization.

Conclusions

  • Newly developed cRGD-platelet-NPs are a safe and promising therapeutic approach for AS.
  • These NPs regulate ABCA1, reduce plaque formation, and enhance cholesterol efflux.
  • The therapeutic mechanism involves suppression of the NF-κB signaling pathway.

Keywords:

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