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Updated: Jun 14, 2025
Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
Published on: April 22, 2016
Base-Dependent Divergent Carbodifluoroalkylation and Halodifluoroalkylation of Alkenes under Visible-Light
Lin Tang1, Fengjuan Jia1, Lufang Zhang1
1College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang, Henan 464000, China.
Abstract:
Organic molecules containing a difluoroalkyl group are valuable and versatile chemicals because of their unique physicochemical and biological properties. Accordingly, the development of efficient and practical difluoroalkylation for the preparation of these compounds is important and attractive. Herein, we demonstrate photoredox-catalyzed and base-dependent selective carbodifluoroalkylation and halodifluoroalkylation of alkenes using readily available 2-(allyloxy)arylaldehydes [or 2-(allylamino)arylaldehydes] and XCF2COOEt (or BrCF2CONR1R2) as starting materials. The developed reaction enables convenient and accurate synthesis of difluoroalkylated chroman-4-ones and aldehydes and features broad substrate scope, mild conditions, and operational simplicity. Moreover, gram-scale product preparation and application of the title protocol in late-stage functionalization of pharmaceutical molecules are accomplished.
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