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Ultra-Photostable Bacterial-Seeking Near-Infrared CPDs for Simultaneous NIR-II Bioimaging and Antibacterial Therapy
Jingyi Duan1,2, Baosheng Li1, Yanqun Liu1,2
1Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, P. R. China.
Advanced Healthcare Materials
|September 3, 2024
Summary
This study introduces novel near-infrared carbonized polymer dots (NIR-CPDs) for simultaneous bacterial imaging and killing. These NIR-CPDs selectively target Staphylococcus aureus, offering a new approach for treating bacterial infections.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Medical Imaging
Background:
- Bacterial infections pose significant health risks and require effective diagnostic and therapeutic solutions.
- Current clinical options for bacterial infections are limited, necessitating innovative approaches.
- Selective targeting and simultaneous treatment of pathogenic bacteria are crucial for managing infections.
Purpose of the Study:
- To develop near-infrared carbonized polymer dots (NIR-CPDs) for in vivo imaging and treatment of bacterial infections.
- To investigate the selective targeting capabilities of NIR-CPDs against specific bacterial strains.
- To evaluate the therapeutic efficacy of NIR-CPDs in a mouse model of bacterial infection.
Main Methods:
- Synthesis of core-shell structured NIR-CPDs with enhanced fluorescence and photostability.
- Evaluation of selective bacterial targeting, distinguishing between Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).
- Assessment of photodynamic therapy effects, including reactive oxygen species generation under 808 nm laser irradiation.
- In vivo experiments on infected mouse models to demonstrate imaging and therapeutic outcomes.
Main Results:
- NIR-CPDs demonstrated increased fluorescence brightness and photostability upon incorporation into bacterial cell membranes.
- NIR-CPDs exhibited selective targeting of S. aureus, while sparing E. coli.
- Photodynamic therapy using NIR-CPDs effectively generated reactive oxygen species, damaging bacterial membranes.
- In vivo studies showed precise imaging and significant therapeutic efficacy, leading to improved wound healing in infected mice.
Conclusions:
- NIR-CPDs offer a dual-functional platform for simultaneous in vivo imaging and photodynamic killing of specific bacterial pathogens.
- The selective targeting and potent therapeutic effects of NIR-CPDs represent a promising advancement in combating bacterial infections.
- This technology holds potential for developing novel diagnostic and therapeutic tools in medicine.
