Metal Halide Perovskite Nanocrystals-Intermediated Hydrogel for Boosting the Biosensing Performance

Area of Science:

• Materials Science
• Nanotechnology
• Analytical Chemistry

Background:

• Metal-halide perovskites offer potential for biosensors but face stability and sensitivity challenges.
• Structural design is crucial for balancing environmental stability and sensing performance in perovskite nanomaterials.

Purpose of the Study:

• To develop a robust and sensitive photoluminescent biosensor for on-site pesticide detection.
• To address the trade-off between stability and sensitivity in perovskite-based biosensors.

Main Methods:

• A trinity strategy was employed, integrating Mn(II) substitution, a CsPb2Cl5 inert shell, and NH2-PEG-COOH coating to create Mn2+-doped CsPbCl3/CsPb2Cl5 core/shell hetero perovskite nanocrystals (PMCP PNCs).
• PMCP PNCs were embedded into a hydrogel system to create a photoluminescent hydrogel biosensor.
• The dual enzyme-triggered responsive property of PMCP PNCs was utilized for pesticide detection.

Main Results:

• The PMCP PNCs exhibited robust water stability and oxygen-sensitive photoluminescence due to the protective core/shell structure and Mn2+ doping.
• The resulting hydrogel biosensor demonstrated ultra-high sensitivity towards chlorpyrifos pesticide, detecting it at the nanogram per milliliter level.
• The biosensor provided accurate on-site pesticide information.

Conclusions:

• The developed PMCP PNCs-based hydrogel biosensor offers a promising platform for accurate and sensitive on-site pesticide detection.
• This work guides the construction of advanced photoluminescent biosensors for various on-site applications.
• The trinity strategy effectively enhances the stability and sensitivity of perovskite nanomaterials for biosensing.