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Assessment of Lipoprotein (a) Levels in Patients with Atherosclerotic Cardiovascular Disease: Single Center
Barış Güngör1, Barış Şimşek1, Tufan Çınar2
1Department of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkiye.
Insights
Elevated lipoprotein (a) [Lp(a)] levels, a significant contributor to residual cardiovascular risk, were found to be higher in women within the Turkish atherosclerotic cardiovascular disease (ASCVD) cohort. A weak but significant correlation was noted between Lp(a) and both total and LDL cholesterol.
Area of Science:
- Cardiology
- Genetics
- Biochemistry
Background:
- Elevated lipoprotein (a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD).
- Regional variations in Lp(a) levels necessitate population-specific data.
- Limited data exists on Lp(a) levels in the Turkish ASCVD population.
Purpose of the Study:
- To evaluate the role of elevated Lp(a) in residual ASCVD risk.
- To assess Lp(a) levels in a Turkish ASCVD cohort.
- To investigate factors influencing Lp(a) levels in this population.
Main Methods:
- Retrospective analysis of data and Lp(a) measurements.
- Inclusion of 1193 consecutive individuals diagnosed with ASCVD.
- Statistical analysis of Lp(a) levels, cholesterol, and demographic data.
Main Results:
- Mean Lp(a) level was 28.2 mg/dL, with 5.8% of patients having levels ≥ 90 mg/dL.
- Lp(a) levels were significantly higher in females compared to males.
- A weak but significant positive correlation was found between Lp(a) and both total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C).
Conclusions:
- Lp(a) concentrations are elevated in women and statin users within the Turkish ASCVD cohort.
- A significant correlation exists between Lp(a) and TC/LDL-C, suggesting a potential link to lipid metabolism.
- Further research is warranted to understand the clinical implications of these findings in the Turkish population.
Objective:
This study aims to evaluate the role of elevated lipoprotein (a) [Lp(a)] levels as a potential contributor to residual risk in individuals with atherosclerotic cardiovascular disease (ASCVD). Considering that approximately 90% of Lp(a) levels are genetically determined and can vary regionally, we assessed Lp(a) levels in a cohort of ASCVD patients from the Turkish population, where data is currently limited.
Methods:
We conducted a retrospective analysis of data and Lp(a) measurements collected from individuals diagnosed with ASCVD at a single center.
Results:
The analysis included Lp(a) levels of 1193 consecutive individuals. The mean Lp(a) level was 28.2 mg/dL, with a median of 16 mg/dL and an interquartile range (IQR) from the 25th to the 75th percentile, 7 mg/dL to 39 mg/dL. The highest recorded Lp(a) level was 326 mg/dL. Among the cases, 18.7% exhibited Lp(a) levels ≥ 50 mg/dL, 10.8% had levels ≥ 70 mg/dL, and 5.8% had levels ≥ 90 mg/dL. The mean levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were 132 ± 47 mg/dL and 212 ± 54 mg/dL, respectively. Lp(a) levels were significantly higher in females compared to males. Furthermore, the proportion of females with Lp(a) levels ≥ 90 mg/dL was higher than in males (11.4% vs. 1.4%; P < 0.01). Additionally, a modest but significant correlation was observed between Lp(a) levels and TC (r = 0.075, P = 0.01) as well as LDL-C (r = 0.106, P < 0.01).
Conclusion:
This study revealed that Lp(a) concentrations were higher in women and statin users among ASCVD patients and identified a weak but significant correlation between Lp(a) levels and both TC and LDL-C.
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