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Related Experiment Video

Updated: Jun 14, 2025

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

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Published on: January 16, 2019

Multiple organ failure: What you need to know.

Scott Brakenridge¹, Lucy Kornblith, Joseph Cuschieri

¹From the Department of Surgery (S.B.), University of Washington, Washington, District of Columbia; and Department of Surgery (L.K., J.C.), University of California San Francisco, San Francisco, California.

The Journal of Trauma and Acute Care Surgery

|September 3, 2024

Summary

Multiple organ failure (MOF) is a critical challenge in acute care surgery. Understanding MOF

Keywords:

Multiple organ failure chronic critical illness immune dysfunction

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Area of Science:

Critical care medicine
Surgical pathology
Immunology

Background:

Multiple organ failure (MOF) presents a significant challenge in acute care surgery, frequently resulting in adverse patient outcomes.
The complexity of MOF necessitates a thorough understanding of its underlying mechanisms for effective clinical management.

Purpose of the Study:

To provide a comprehensive review of Multiple Organ Failure (MOF) and chronic critical illness.
To explore the etiology, pathophysiology, clinical presentation, diagnosis, management, prognosis, and prevention of MOF.

Main Methods:

This study is a comprehensive literature review.
It synthesizes current knowledge on MOF and chronic critical illness.

Main Results:

MOF involves intricate inflammatory, immune, and microvascular disturbances.
Effective management requires addressing these complex pathophysiological pathways.

Conclusions:

Understanding MOF etiology and pathophysiology is crucial for developing targeted treatments.
Mitigating underlying disturbances can improve patient recovery trajectories.