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Targeting SIRT2 in Aging-Associated Fibrosis Pathophysiology

Yongjiao Huang1,2,3, Wei He1,3,4, Yingting Zhang1

  • 1Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aging and Disease
|September 3, 2024
PubMed
Summary

Aging accelerates fibrosis by accumulating senescent cells. Sirtuin 2 (SIRT2), a key enzyme, plays a vital role in liver, kidney, and heart fibrosis during aging, offering a potential therapeutic target.

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