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Updated: Jun 14, 2025

Analysis of Epididymal Protein Synthesis and Secretion
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Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression

Natalie A Trigg1, Colin C Conine1

  • 1Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Departments of Genetics and Pediatrics - Penn Epigenetics Institute, Institute of Regenerative Medicine, and Center for Women's Health and Reproductive Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Cell Reports
|September 3, 2024
PubMed
Summary

Sperm acquire microRNAs (miRNAs) from the epididymis, crucial for regulating embryonic gene expression. This study reveals how sperm small RNAs are gained during transit and impact offspring development.

Keywords:
CP: Developmental biologyembryogenesisepididymisepididymosomesepigenetic inheritancemale fertilitymicroRNAspreimplantation developmentreproductionspermatozoa

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