Prospective Multi-Center Longitudinal Study to Validate Accuracy of the Global Anatomic Staging System (GLASS) Score in Predicting Major Acute Limb Events in Patients With Chronic Limb Threatening Ischemia Undergoing Endovascular Intervention: The PROMOTE-GLASS Study Protocol

Maram Darwish ^1,2, Mario D'Oria ^3,4, Alexander Croo ⁵

⁰Southeast Wales Vascular Network, University Hospital of Wales, Cardiff, UK.

Vascular and Endovascular Surgery +

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September 3, 2024

View abstract on PubMed

Summary

The Global Limb Anatomic Staging System (GLASS) shows promise in predicting outcomes for chronic limb-threatening ischemia (CLTI) patients undergoing endovascular treatment (EVT). This study validates GLASS for improved patient selection and treatment planning in CLTI cases.

Area Of Science

Vascular Surgery
Interventional Cardiology
Health Services Research

Background

The Global Limb Anatomic Staging System (GLASS) is an angiographic scoring system for infrainguinal disease extent in endovascular treatment (EVT).
No current risk prediction model exists for chronic limb-threatening ischemia (CLTI) patients undergoing EVT.
GLASS validation and adoption for research outside academic institutions are limited.

Purpose Of The Study

To examine the validity and reliability of the GLASS score in predicting major acute limb events and overall survival (OS).
To assess GLASS's utility in patients with CLTI undergoing EVT.
To improve clinical decision-making and patient outcomes for CLTI.

Main Methods

A prospective, international, multicenter, observational study (PROMOTE-GLASS).
Inclusion of patients with CLTI referred for EVT.
Assessment of primary outcomes (technical success/failure, 1-year limb patency) and secondary outcomes (adverse limb events, amputation, OS) up to 1 year post-procedure.

Main Results

Data collection and analysis are ongoing as part of the PROMOTE-GLASS study.
Validation of risk prediction through clinical and imaging data analysis at follow-up.
The study aims to provide robust evidence for GLASS's predictive capabilities.

Conclusions

PROMOTE-GLASS has the potential to revolutionize clinical decision-making for EVT in CLTI patients.
The study findings may help identify patients likely to benefit from EVT, reducing the need for invasive procedures.
Results will inform patient selection for future randomized controlled trials (RCTs) investigating EVT for CLTI.

Keywords:

chronic limb threatening ischemia (CLTI) endovascular revascularization global anatomical staging system (GLASS) study protocol