Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in Bubalus bubalis and Ovis aries.

Immunogenetics·2026
Same author

Bioorthogonally reinforced injectable granular hydrogels synergizing ECM mimicry with microporosity for skin tissue engineering.

Biomaterials science·2026
Same author

A 3D-bioprinted hydrogel platform with tunable matrix stiffness reveals mechanical adaptation and doxorubicin resistance in triple-negative breast cancer.

Journal of materials chemistry. B·2026
Same author

3D-printed skeletal tissue analogues using bone decellularized extracellular Matrix with PCL-bioglass composite: A biomimetic approach.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Agriculture-related musculoskeletal disorders among farming populations in rural India: focus on vulnerable communities - protocol for a scoping review.

BMJ public health·2026
Same author

Racial and Ethnic Disparities in the Diagnosis and Treatment of Obstructive Sleep Apnea: A Systematic Review.

International journal of environmental research and public health·2026

Related Experiment Video

Updated: Jun 14, 2025

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.9K

NIR-Responsive Deployable and Self-Fitting 4D-Printed Bone Tissue Scaffold.

Saswat Choudhury1, Akshat Joshi1, Akhilesh Agrawal1

  • 1Department of Bioengineering, Indian Institute of Science, C.V. Raman Avenue, Bangalore 560012, India.

ACS Applied Materials & Interfaces
|September 3, 2024
PubMed
Summary
This summary is machine-generated.

This study presents 3D-printed, NIR-responsive scaffolds made of polylactide-co-trimethylene carbonate and polydopamine nanoparticles. These self-fitting scaffolds promote significant bone regeneration in critical-sized defects.

Keywords:
NIRadditive manufacturingbiomaterialsbone scaffoldsself-fittingshape memory

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.6K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K

Related Experiment Videos

Last Updated: Jun 14, 2025

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.9K
Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.6K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Treating irregular and critical-sized bone defects remains a significant clinical challenge.
  • Minimally invasive implantation of deployable, self-fitting tissue scaffolds offers a promising therapeutic approach.
  • Developing advanced materials with controlled shape-memory properties is crucial for effective bone defect repair.

Purpose of the Study:

  • To fabricate novel near-infrared (NIR) responsive and programmable polylactide-co-trimethylene carbonate (PLMC) scaffolds nanoengineered with polydopamine nanoparticles (PDA) using 3D printing.
  • To evaluate the shape recovery, osteogenic potential, and in vivo bone regeneration capabilities of these PLMC-PDA composite scaffolds.
  • To demonstrate the intraoperative deployability and self-fitting characteristics of the scaffolds in irregular bone defects.

Main Methods:

  • Extrusion-based 3D printing was employed to fabricate PLMC-PDA composite scaffolds.
  • Scaffolds were characterized for shape recovery under NIR irradiation, assessing speed, efficiency, and tunability.
  • In vitro osteogenic potential was evaluated by measuring alkaline phosphatase (ALP) secretion and mineral deposition.
  • In vivo studies involved implanting scaffolds in critical-sized rabbit cranial bone defects to assess bone regeneration via microcomputed tomography (micro-CT).
  • Ex vivo models of rabbit tibia, mandible, and tooth defects were used to confirm scaffold self-fitting capabilities.

Main Results:

  • The 3D-printed PLMC-PDA scaffolds exhibited excellent (>99%), rapid (<30 s), and tunable shape recovery upon NIR irradiation.
  • PLMC-PDA composites showed significantly enhanced osteogenic potential in vitro compared to neat PLMC, evidenced by increased ALP secretion and mineral deposition.
  • In vivo implantation in rabbit cranial defects resulted in near-complete bone regeneration at 6 and 12 weeks for PLMC-PDA scaffolds, outperforming neat PLMC.
  • Scaffolds demonstrated effective intraoperative self-fitting into irregular defects under low-power NIR irradiation.

Conclusions:

  • The developed 3D-printed PLMC-PDA composite scaffolds are NIR-responsive, programmable, and possess excellent self-fitting capabilities for minimally invasive deployment.
  • These scaffolds significantly enhance in vitro osteogenesis and promote substantial in vivo bone regeneration in critical-sized defects.
  • The findings confirm the clinical potential of these innovative composite scaffolds for addressing complex and irregular bone defects, offering a new strategy for bone tissue regeneration.