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Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

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Related Experiment Video

Updated: Jun 25, 2026

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
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Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

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The Mitris RESILIA Valve: New Skin for a Proven Design.

Giulia Ciccarelli1, Luca Weltert2, Raffaele Scaffa2

  • 1Cardiac Surgery Division, University of Padua, Padua, Italy.

Surgical Technology International
|September 3, 2024
PubMed
Summary
This summary is machine-generated.

The new mitris valve combines excellent hemodynamic performance and durability, featuring a pliable cuff for improved mitral valve fit and reduced complications. Its design enhances implantability and may offer longer-lasting performance.

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Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Medical Device Engineering

Background:

  • The Carpentier-Edwards PERIMOUNT Magna Mitral Ease valve offered excellent hemodynamic performance.
  • INSPIRIS RESILIA tissue provided enhanced durability through advanced pericardial treatment.
  • A need existed for a mitral valve prosthesis combining these advantages.

Purpose of the Study:

  • To introduce the novel mitris valve, integrating key features of existing successful devices.
  • To report on the feasibility and initial impressions of the first mitris valve implantation.
  • To highlight design improvements enhancing mitral valve specific implantation and durability.

Main Methods:

  • Development of the mitris valve by combining PERIMOUNT Magna Mitral Ease valve features with INSPIRIS RESILIA tissue.
  • Surgical implantation of the mitris valve.
  • Evaluation of implantability, anatomical fit, and potential complications.

Main Results:

  • The mitris valve demonstrated comparable implantability to previous generations without added challenges.
  • Its pliable, saddle-shaped sewing cuff with lower stent height improved fit to the mitral annulus.
  • Potential benefits include reduced risk of left ventricle outflow obstruction and improved tissue stress.

Conclusions:

  • The mitris valve successfully integrates superior hemodynamic performance and durability.
  • Its design offers enhanced implantability and anatomical adaptation for mitral valve replacement.
  • The INSPIRIS RESILIA tissue technology suggests improved long-term durability, reinforcing device trustworthiness.