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Role of UCHL3 in health and disease

Hu Lei1, Hanzhang Xu1, Yingli Wu2

  • 1Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Biochemical and Biophysical Research Communications
|September 3, 2024
PubMed

Insights

Ubiquitin C-terminal hydrolase 3 (UCHL3) is vital for cell functions like DNA repair and protein homeostasis. Dysregulation of UCHL3 is linked to cancer and neurodegenerative diseases, making it a key therapeutic target.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Ubiquitin C-terminal hydrolase 3 (UCHL3) is a cysteine protease.
  • UCHL3 performs deubiquitination and deneddylation, crucial for protein homeostasis.
  • UCHL3 dysregulation is implicated in cancer and neurodegenerative diseases.

Purpose of the Study:

  • To review the cellular processes regulated by UCHL3.
  • To explore UCHL3's role in health and disease.
  • To discuss the development of UCHL3 inhibitors.

Main Methods:

  • Literature review of UCHL3 functions.
  • Analysis of studies on UCHL3, including knockout mice models.
  • Examination of UCHL3's role in various cellular processes and disease states.

Main Results:

  • UCHL3 is essential for cell cycle regulation, DNA repair, and apoptosis.
  • UCHL3 stabilizes oncoproteins, making it a cancer therapeutic target.
  • UCHL3 dysfunction is linked to learning deficits, stress responses, and retinal degeneration.

Conclusions:

  • UCHL3 is a significant enzyme with broad physiological roles.
  • Understanding UCHL3 mechanisms is critical for developing treatments for cancer and neurodegenerative disorders.
  • Further research is needed to fully elucidate UCHL3's functions and therapeutic potential.
Keywords:
DeneddylationDeubiquitinaseDeubiquitinationDiseaseUCHL3

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