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Updated: Jun 11, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
A chlorin e6 derivative-mediated photodynamic therapy for mild to moderate acne: A prospective, single-blind,
Haiyan Zhang1, Yan Zhao1, Hui Tao1
1Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, PR China.
Background:
Acne vulgaris is a chronic inflammatory skin disease involving the pilosebaceous unit.
Objective:
To assess the efficacy and safety of a chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) in the treatment of mild to moderate acne patients.
Methods:
In this prospective patient single-blind randomized split-face controlled study, patients diagnosed with mild to moderate acne were treated with four sessions of STBF-PDT on one-half of the face, while the other half were treated with the same dose of red-light treatment without photosensitizer. Follow-up assessment including the skin lesion clearance rate, facial fluorescence scattering spots on VISIA Porphyrins mode, and skin physiological parameters was conducted before and after treatment as well as 2 and 4 weeks after the final treatment.
Results:
A total of 26 patients were recruited, of which 22 patients completed this study. STBF-PDT is significantly effective in improving lesions in patients with acne. The clearance rate of total lesions was 67.42±8.51 % in the STBF-PDT group and 41.05±11.97 % in the control group 4 weeks after the treatment (P < 0.001). The average clearance rate of inflammatory lesions was 84.41±7.13 % in the STBF-PDT group and 50.10±13.91 % in the control group, with a statistically significance (P < 0.0001). The skin sebum of the STBF-PDT side was significantly lower than that on the control side. There was no obvious adverse reaction especially no pain or reactive acne.
Conclusion:
STBF-PDT may be a safe and effective treatment for mild to moderate acne and can significantly inhibit sebum secretion.
