Different patterns of blood sugar and serum insulin levels after different glucose preparations

In a group of 20 in-patients oral glucose tolerance test was performed repeatedly using 100 g of glucose in weak tea and the same amount of glucose in form of commercial flavoured preparation Glukosa Test. Blood sugar (BS) and immunoreactive insulin (IRI) were estimated in venous blood at intervals 0, 30, 60, 90, 120 and 180 mins, respectively. During the test the values of BS alter Glukosa Test were lower at 120 and 180 mins interval than after the pure glucose. The values of IRI after Glukosa Test were higher from 60 to 120 mins interval. Insulinogenic index was therefore significantly higher at 30, 60 and 90 mins interval and in summarized value for the entire test. Our findings of different effects of the same amount of glucose administered in various forms on pattern of blood sugar and insulin cannot been explained from our material. The possibility of different activation of some regulatory mechanism--e.g. so called enteroinsular axis--should be considered.