Related Experiment Video
Updated: Jun 25, 2026
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Comparative analysis of imaging features and stroke-related factors between posterior circulation atherosclerosis and
1Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, China.
Insights
High-resolution vessel wall imaging (HR-VWI) reveals distinct features differentiating posterior circulation atherosclerosis from intramural hematoma (IMH)-type dissection. Arterial remodeling capacity is a key indicator of stroke risk in both conditions.
Area of Science:
- Neuroimaging
- Vascular Neurology
- Radiology
Background:
- Posterior circulation atherosclerosis and intramural hematoma (IMH)-type dissection present diagnostic challenges.
- High-resolution magnetic resonance vessel wall imaging (HR-VWI) offers detailed insights into vessel wall morphology.
Purpose of the Study:
- To compare HR-VWI features between posterior circulation atherosclerosis and IMH-type dissection.
- To identify imaging indicators associated with cerebral ischemic events in these conditions.
Main Methods:
- Retrospective analysis of clinical and HR-VWI data from 55 patients with IMH-type dissection and 132 with atherosclerosis.
- Independent feature extraction by two radiologists.
- Multivariable logistic regression to identify stroke risk factors.
Main Results:
- IMH-type dissection patients were younger with lower prevalence of diabetes and hypertension, and different imaging profiles (higher intraluminal thrombus, wall area, total vessel area; lower enhanced grade, remodeling index).
- In stroke patients, IMH-type dissection was associated with higher remodeling index, wall area, total vessel area, and intraluminal thrombus.
- Remodeling index and normalized wall index were risk factors for stroke in dissection, while lumen area and normalized wall index were risk factors for atherosclerotic stroke.
Conclusions:
- Posterior circulation IMH-type dissection demonstrates greater positive remodeling potential compared to atherosclerosis.
- Arterial remodeling capacity is significantly correlated with stroke risk in these posterior circulation pathologies.
Aim:
To compare the features detected by high resolution magnetic resonance vessel wall imaging (HR-VWI) between posterior circulation atherosclerosis and intramural hematoma (IMH)-type dissection, and to identify indicators related to cerebral ischemic events.
Materials And Methods:
Clinical and HR-VWI data of 55 patients with posterior circulation IMH-type dissection and 132 patients with posterior circulation atherosclerosis collected between October 2017 and October 2023 were analyzed retrospectively. Two radiologists independently extracted the imaging features. Multivariable logistic regression was used to identify factors independently associated with stroke.
Results:
Compared with patients with atherosclerosis, those with IMH-type dissection were younger, with a lower prevalence of diabetes and hypertriglyceridemia, lower hypertension grade, enhanced grade, remodeling index (RI), vertebrobasilar artery/brainstem ratio, and prevalence of nonsmooth surface, and higher prevalence of intraluminal thrombus (ILT), lumen (LA), wall area (WA), and total vessel area (TVA). In patients with stroke, those with IMH-type dissection were younger, with a lower prevalence of diabetes, and degree of hypertension, and higher RI, WA, TVA, and the prevalence of ILT. Multivariable logistic regression showed that RI (odds ratio [OR], 0.37; 95% CI, 0.17-0.77) and normalized wall index (NWI) (OR, 39.02; 95% CI, 2.19-695.35) were risk factors for stroke in patients with dissection, and LA (OR, 1.52; 95% CI, 1.12-2.06) and NWI (OR, 60.84; 95% CI 3.70-998.06) were risk factors for atherosclerotic stroke.
Conclusion:
Patients with posterior circulation IMH-type dissection had greater potential for positive remodeling than those with atherosclerosis. The arterial remodeling capacity was closely related to stroke risk.
More Related Videos
06:45Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
Published on: June 2, 2023
05:32Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
Related Concept Videos
01:17Hemorrhagic Stroke l: Introduction
01:29Hemorrhagic Stroke ll: Pathophysiology