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Murine Fecal Isolation and Microbiota Transplantation

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Causation between the gut microbiota and inguinal hernia: a two-sample double-sided Mendelian randomization study.

Changyuan Wu¹, Yujin Zhu², Hongwei Xi³

¹Department of Pediatrics, Shanxi Medical University, Taiyuan, People's Republic of China.

Scientific Reports

|September 3, 2024

Summary

This study used Mendelian randomization to investigate the gut microbiota

Keywords:

Causal inference Gut microbiota Inguinal hernia Mendelian randomization

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Area of Science:

Genetics and Microbiology
Gastroenterology
Surgical Conditions

Background:

Inguinal hernias are common, often linked to abdominal muscle defects.
Gut microbiota influences skeletal muscle aging, but its role in inguinal hernias is unknown.

Purpose of the Study:

To determine the causal relationship between gut microbiota and inguinal hernia risk.
To explore potential therapeutic targets within the gut microbiome.

Main Methods:

Two-sample, bidirectional Mendelian randomization analysis.
Utilized genome-wide association study (GWAS) data for gut microbiota and inguinal hernia.
Employed various statistical methods including Inverse Variance Weighted (IVW) and MR Egger regression.

Main Results:

Identified 8 bacterial traits with a negative causal effect on inguinal hernia.
Reverse Mendelian randomization showed 6 bacterial traits positively correlated with inguinal hernia.
Sensitivity analyses confirmed the reliability of the findings, with no significant heterogeneity or pleiotropy.

Conclusions:

Specific gut bacteria negatively impact inguinal hernia risk, while others are positively associated.
Modulating gut microbiota composition may offer a novel strategy for managing inguinal hernias.
Findings suggest a significant role for the gut microbiome in the pathogenesis of inguinal hernia.