Prognostic risk factors for pyogenic liver abscess caused by Klebsiella pneumoniae
1Department of Hepatobiliary Surgery, Dongyang People's Hospital, Affiliated Dongyang Hospital of Wenzhou Medical University, 60 West Wuning Road, Dongyang, Zhejiang, 322100, P.R. China. lvyunxiao1986@gmail.com.
Background:
Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of organ dysfunction in PLA have been implicated. However, few studies to date have explored the most common risk factors for clinical severity.
Methods:
We conducted a study on patients with PLA caused by Klebsiella pneumoniae between February 2013 and December 2022.Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission.
Results:
After included 200 patients, we found that an elevated procalcitonin (PCT) level (p = 0.03), higher glucose level (p = 0.03), and lower total cholesterol (TC) level (p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (p = 0.02) and lower TC level (p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (p < 0.01) was associated with a higher probability of ICU admission.
Conclusion:
In patients with PLA caused by Klebsiella pneumoniae, the PCT, glucose, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.
Insights
Procalcitonin, glucose, and total cholesterol levels are key indicators for Klebsiella pneumoniae pyogenic liver abscess severity. These markers help predict positive blood cultures, septic shock, and ICU admission in patients.
Area of Science:
- Infectious Diseases
- Hepatology
- Critical Care Medicine
Background:
- Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae presents variable severity.
- Risk factors for organ dysfunction in PLA are known, but common clinical severity predictors are underexplored.
Purpose of the Study:
- To identify clinical factors associated with severe outcomes in Klebsiella pneumoniae PLA.
- To investigate predictors of positive blood culture, septic shock, and ICU admission.
Main Methods:
- Retrospective study of 200 patients with Klebsiella pneumoniae PLA (February 2013 - December 2022).
- Logistic regression analysis to identify factors associated with positive blood culture, septic shock, and ICU admission.
Main Results:
- Elevated procalcitonin (PCT), higher glucose, and lower total cholesterol (TC) linked to positive blood cultures.
- Increased PCT and lower TC associated with higher risk of septic shock.
- Higher PCT levels correlated with increased probability of ICU admission.
Conclusions:
- PCT, glucose, and TC levels are significant predictors of clinical severity in Klebsiella pneumoniae PLA.
- These biomarkers can aid in early risk stratification and management of PLA patients.
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