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Factors affecting human in vitro fertilization: a multifactorial study.

J de Mouzon, B Lefèvre, R Frydman

    Fertility and Sterility
    |June 1, 1985
    PubMed
    Summary
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    Optimizing in vitro fertilization (IVF) involves selecting the best cycle stimulation regimen and considering semen quality. These factors significantly impact oocyte cleavage rates, crucial for successful fertilization outcomes.

    Area of Science:

    • Reproductive Medicine
    • Embryology
    • In Vitro Fertilization

    Background:

    • Oocyte cleavage rate is a critical indicator of fertilization success in IVF.
    • Several factors can influence oocyte maturation and subsequent cleavage.

    Purpose of the Study:

    • To investigate the multifactorial influence of cycle stimulation, cumulus cell appearance, semen quality, and incubation time on the cleavage rate of mature oocytes in IVF.
    • To identify key factors that can be optimized for improved IVF outcomes.

    Main Methods:

    • Logistic regression analysis was employed to assess the independent and interactive effects of four factors on oocyte cleavage.
    • Data from 705 mature oocytes undergoing IVF were analyzed.

    Main Results:

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    • Cycle stimulation regimen was the most significant factor influencing cleavage rate, with human menopausal gonadotropin combined with clomiphene citrate yielding superior results compared to clomiphene citrate alone.
    • Semen quality also demonstrated a significant influence on oocyte cleavage.
    • Incubation time did not show a significant impact on cleavage rates.
    • An interaction was observed between the stimulation treatment and the appearance of the cumulus cell mass.

    Conclusions:

    • Optimizing the ovarian stimulation protocol is paramount for enhancing IVF success rates.
    • Semen quality assessment and potential partner selection should be considered to improve fertilization outcomes.
    • Further research into the interaction between stimulation protocols and oocyte quality indicators like cumulus cell mass is warranted.