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The Risk of Deep Vein Thrombosis and Optimal Timing of Breast Cancer Surgery After COVID-19 Infection

  • 0Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Journal of Breast Cancer +

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September 4, 2024

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September 4, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Breast cancer surgery patients with COVID-19 face a higher risk of deep vein thrombosis (DVT). Delaying surgery for at least two weeks post-infection significantly reduces this risk.

Area Of Science

  • Oncology
  • Infectious Diseases
  • Vascular Surgery

Background

  • The COVID-19 pandemic has impacted surgical care for cancer patients.
  • Deep vein thrombosis (DVT) is a known complication following surgery, particularly in cancer patients.
  • Understanding the interplay between COVID-19 infection and postoperative DVT risk is crucial for optimizing surgical timing.

Purpose Of The Study

  • To evaluate the risk of postoperative deep vein thrombosis (DVT) in breast cancer patients who have had coronavirus disease 2019 (COVID-19).
  • To determine the optimal timing for breast cancer surgery in the post-pandemic era, considering COVID-19 status.
  • To assess the association between the timing of surgery relative to COVID-19 infection and DVT risk.

Main Methods

  • Prospective study comparing breast cancer patients who had COVID-19 and underwent surgery (n=577) with a control group without COVID-19 (n=327).
  • Patients were stratified based on the interval between COVID-19 infection and surgical intervention.
  • Logistic regression analysis was employed to determine the risk factors for DVT.

Main Results

  • Patients with a history of COVID-19 exhibited a higher incidence of postoperative DVT (3.64%) compared to the control group (1.21%).
  • Surgery performed within two weeks of COVID-19 infection was associated with a significantly increased DVT risk (OR, 10.556; p=0.003).
  • Delaying surgery to two weeks or more post-infection reduced DVT rates to 2.85%, with all DVT cases resolving without serious complications.

Conclusions

  • Performing breast cancer surgery within two weeks of a COVID-19 infection requires caution due to elevated DVT risk.
  • While a slight DVT risk elevation persists beyond two weeks, surgery is generally considered safe given treatment urgency.
  • The timing of surgery relative to COVID-19 infection did not adversely affect subsequent anti-tumor therapy or lead to serious complications.

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