Related Experiment Video
Updated: May 12, 2026
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Application value of P-selectin and Clara cell secretory protein 16 expression in children with severe adenovirus
Lin Yuan1, Yunyan Yang2, Jingjing Huang1
1Department of Infectious Disease, Xiamen Children's Hospital/Children's Hospital of Fudan University at Xiamen/State-level Regional Children's Medical Center, Xiamen, Fujian, China.
Insights
P-selectin and Clara cell secretory protein 16 (CC16) levels are key indicators in severe adenovirus (ADV) pneumonia. Elevated P-selectin and decreased CC16 effectively predict disease severity in children.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Biomarker Discovery
Background:
- Adenovirus (ADV) pneumonia is a significant cause of respiratory illness in children.
- Identifying reliable biomarkers for severe ADV pneumonia is crucial for timely intervention.
- P-selectin and CC16 are implicated in inflammatory and lung injury processes.
Purpose of the Study:
- To investigate the roles of P-selectin and CC16 in severe ADV pneumonia pathogenesis.
- To evaluate the predictive value of P-selectin and CC16 for disease severity.
- To establish potential diagnostic thresholds for these biomarkers.
Main Methods:
- Retrospective study of 51 children with ADV pneumonia (mild vs. severe groups) and 30 healthy controls.
- Univariate analysis of clinical and laboratory parameters including P-selectin and CC16.
- Logistic regression and ROC curve analysis to determine independent risk factors and predictive values.
Main Results:
- Severe ADV pneumonia group showed increased white blood cell count, C-reactive protein, procalcitonin, d-dimer, and P-selectin levels.
- Significantly decreased CC16 levels were observed in the severe group compared to the mild group (p < 0.05).
- P-selectin and CC16 were identified as independent risk factors for severe ADV pneumonia, with high predictive value.
Conclusions:
- P-selectin and CC16 levels are significantly correlated with the severity of ADV pneumonia in children.
- Specific thresholds (P-selectin > 898.58 pg/mL, CC16 < 11.355 ng/mL) can predict severe ADV pneumonia.
- These biomarkers offer valuable insights into ADV pneumonia pathogenesis and severity assessment.
Abstract:
This study investigated the roles of P-selectin and Clara cell secretory protein 16 (CC16) levels in the pathogenesis of severe adenovirus (ADV) pneumonia in children and evaluated their ability to predict disease. Fifty-one children (age, 1-5 years) with ADV pneumonia who were admitted to Xiamen Children's Hospital were included in this study and divided into the mild group (24 patients) and severe group (27 patients). A control group comprising healthy children of the same age who underwent routine physical examinations during the same period (30 patients) was also included. The univariate analysis demonstrated that the levels of the white blood cell count and C-reactive protein, procalcitonin, d-dimer, and P-selectin were increased in a severe group compared with a mild group, while CC16 levels were significantly decreased (p < 0.05). The logistic regression analysis revealed that P-selectin and CC16 levels were independent risk factors for severe ADV pneumonia in children. The areas under the ROC curves suggested that P-selectin and CC16 exhibited high predictive value for severe ADV pneumonia. P-selectin values more than 898.58 pg/mL and CC16 values less than 11.355 ng/mL predicted severe ADV pneumonia. P-selectin and CC16 levels are correlated with the severity of ADV pneumonia in children.
More Related Videos
09:20Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay
Published on: April 28, 2014
06:03Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
