Rhinocerebral mucormycosis: A clinicopathological analysis of COVID-19-associated mucormycosis
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View abstract on PubMed
Summary
This summary is machine-generated.Post-COVID mucormycosis, a fungal infection, increased during the pandemic. Histopathology is crucial for early diagnosis and successful treatment of this potentially fatal condition.
Area Of Science
- Medical Mycology
- Infectious Diseases
- Pathology
Background
- The coronavirus disease 2019 (COVID-19) pandemic saw a rise in mucormycosis incidence.
- This fungal infection predominantly affected individuals with a history of COVID-19.
Purpose Of The Study
- To investigate risk factors associated with mucormycosis in post-COVID-19 patients.
- To analyze the clinical and histopathological characteristics of mucormycosis following COVID-19 infection.
Main Methods
- A retrospective study was conducted in a dedicated COVID-19 hospital over two months.
- Histopathology of surgical specimens was the gold standard for confirming mucormycosis.
- Confirmed cases were analyzed for clinico-radiological, histopathological, and microbiological features.
Main Results
- Nine out of 25 suspected cases were histopathologically confirmed as mucormycosis.
- Diabetes mellitus was a significant comorbidity, with higher necrosis proportion observed in diabetic patients.
- Features like angioinvasion, soft-tissue invasion, Splendor-Hoeppli phenomenon, and neural invasion were noted. Mixed infections with Aspergillus were present in three diabetic patients.
Conclusions
- Post-COVID mucormycosis can have fatal outcomes.
- Early diagnosis and prompt treatment are essential for successful management.
- Histopathological examination provides an early and reliable method for diagnosing mucormycosis.
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