DOTATATE PET Imaging in Olfactory Neuroblastoma and Association with SSTR Expression

Area of Science:

• Oncology
• Nuclear Medicine
• Radiology

Background:

• Olfactory neuroblastoma (ONB) is a rare nasal cavity tumor.
• Somatostatin receptors (SSTRs) are often expressed in ONB.
• Ga-68 DOTATATE PET/CT is a potential imaging modality for ONB.

Purpose of the Study:

• To evaluate the utility of Ga-68 DOTATATE PET/CT in patients with olfactory neuroblastoma.
• To assess the correlation between SSTR2 expression and DOTATATE avidity in ONB.

Main Methods:

• Retrospective review of 96 endoscopic endonasal skull base surgery cases for ONB.
• Histo (H) scores and normalized DOTATATE standardized uptake values (nSUVs) were measured.
• Nine ONB patients were included.

Main Results:

• All included ONBs showed positive SSTR2 expression (mean H-score: 180).
• All ONBs demonstrated DOTATATE avidity (mean nSUV: 6.7).
• No significant correlation was found between H-score and nSUV (r² = 0.24, p = 0.18).

Conclusions:

• SSTR2 expression is consistently present in ONB.
• DOTATATE avidity is observed in all ONBs.
• Ga-68 DOTATATE PET/CT may be a valuable imaging tool for monitoring recurrent and metastatic ONB.