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The CALERIE™ Genomic Data Resource.

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Caloric restriction (CR) in humans shows potential for slowing aging, similar to animal studies. This study provides the first public genomic data from a human CR trial, aiding aging research.

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Area of Science:

  • Gerontology
  • Genomics
  • Molecular Biology

Background:

  • Caloric restriction (CR) is known to slow biological aging and extend lifespan in model organisms.
  • The CALERIE-2 trial provided the first randomized, controlled human data on long-term CR in non-obese individuals.
  • Understanding the molecular mechanisms of CR in humans is crucial for aging research.

Purpose of the Study:

  • To generate and provide a comprehensive genomic dataset from the CALERIE-2 trial.
  • To facilitate research into the molecular pathways and biological processes affected by CR in humans.
  • To establish the first publicly accessible multi-omic, longitudinal data resource for a human aging intervention trial.

Main Methods:

  • Generated whole-genome SNP genotypes from 218 participants.
  • Collected longitudinal DNA methylation, mRNA, and small RNA data at three time points.
  • Utilized blood, skeletal muscle, and adipose tissue samples (n=2327 total samples).

Main Results:

  • Created a unique, multi-tissue, multi-omic, longitudinal dataset from a human CR trial.
  • The CALERIE Genomic Data Resource is now publicly available via the Aging Research Biobank.
  • This resource enables in-depth analysis of CR's molecular effects in humans.

Conclusions:

  • The CALERIE Genomic Data Resource is a valuable asset for translational geroscience.
  • This data can significantly advance our understanding of how CR impacts human aging at a molecular level.
  • Further research using this resource is expected to uncover new insights into aging biology and potential interventions.