Clinicohistopathological Correlation and Prognostic Significance of Molecular Biomarkers in Urinary Bladder Neoplasms: A Comprehensive Analysis

Avinash Mane ¹, Nanda J Patil ¹, Atul B Hulwan ¹

⁰Department of Pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.

Cureus +

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September 4, 2024

View abstract on PubMed

Summary

This study found that specific molecular biomarkers and genetic alterations in bladder cancer correlate with advanced tumor stages and poorer survival. Integrating these markers aids in better risk stratification and personalized treatment for bladder neoplasms.

Area Of Science

Oncology
Molecular Biology
Urology

Background

Urinary bladder neoplasms are diverse tumors requiring better prognostic tools.
Understanding molecular biomarkers is crucial for personalized bladder cancer treatment.

Purpose Of The Study

To investigate clinicopathological correlations of molecular biomarkers in bladder neoplasms.
To assess the prognostic significance of these biomarkers for patient outcomes.

Main Methods

Prospective observational study of 174 bladder neoplasm patients.
Collected clinicopathological data and analyzed tissue samples using IHC, FISH, and molecular profiling.
Monitored disease progression, recurrence, and survival through longitudinal follow-up.

Main Results

Elevated p53, Ki-67, and EGFR expression linked to advanced stages and higher grades (p < 0.001).
Genetic alterations correlated with aggressive phenotypes and increased recurrence risk (p < 0.01).
Higher biomarker levels/alterations associated with poorer treatment response and shorter survival.

Conclusions

Clinicopathological parameters and molecular biomarker data are vital for bladder cancer risk stratification.
Integration of these data aids in treatment selection and prognostic assessment.
This approach supports personalized medicine strategies for urinary bladder neoplasms.

Keywords:

bladder cancer molecular biomarkers neoplasms prognostic significance urinary bladder