Next generation probiotics for human health: An emerging perspective

Area of Science:

• Microbiology
• Gastroenterology
• Biotechnology

Background:

• The human gut microbiome plays a vital role in host health.
• Next-generation probiotics (NGP) are beneficial gut microbes with therapeutic potential.
• Challenges exist in NGP production, including nutritional needs and oxygen sensitivity.

Purpose of the Study:

• To provide a comprehensive overview of next-generation probiotics.
• To discuss their health benefits, regulatory landscape, and risk assessment.
• To identify criteria for commercialization in food and pharmaceutical sectors.

Main Methods:

• Literature review of scientific publications on next-generation probiotics.
• Analysis of health benefits, technological hurdles, and regulatory considerations.
• Evaluation of risk assessment for potential NGP candidates.

Main Results:

• NGP candidates include genera like Bacteroides, Faecalibacterium, Akkermansia, and Clostridium.
• Unlike traditional probiotics, some NGP, such as Bacteroides and Clostridium, may have ambiguous infectious disease potential.
• Technological hurdles in NGP production necessitate advanced delivery systems.

Conclusions:

• Next-generation probiotics hold significant promise as biotherapeutics and supplements.
• Addressing production challenges and conducting thorough risk assessments are crucial for NGP commercialization.
• Regulatory frameworks need to accommodate the unique characteristics of NGP for safe market entry.